Journal of Advanced Clinical and Research Insights

Vol. 4 | No.1 | January-February 2017 Issue

1.EDITORIAL

What do the microRNA signatures have to say about oral squamous cell carcinoma?

M. G. Madhura

Year:2017 | Month:January-February | Volume:4 | Number:1 | Pages No:1–2 | No. of Hits: 269


ABSTRACT

Oral squamous cell carcinoma (OSCC), the most common type of head and neck squamous cell carcinoma (HNSCC) ranks eighth worldwide.[1] The poor prognosis related to OSCC in majority of the instances is either due to delayed diagnosis or the disease presenting at an advanced stage.[2] The earlier and more precise diagnosis of OSCC may be facilitated by the use of reliable molecular markers which in addition help in determining the prognosis.

How to cite this article: Madhura MG, What do the microRNA signatures have to say about oral squamous cell carcinoma? J Adv Clin Res Insights 2017;4:1-2.


2.ORIGINAL ARTICLE

Efficacy of intravenous, intramassetric, and submucosal routes of dexamethasone administration after impacted third molar surgery: A randomized, comparative clinical study

G. K. Vivek, N. Vaibhav, Adil Shafath, Mohammad Imran

Year:2017 | Month:January-February | Volume:4 | Number:1 | Pages No:3–7 | No. of Hits: 244


ABSTRACT

Purpose: The aim of the study is to compare the efficacy of intravenous (IV), intramassetric (IM), and submucosal (SM) routes of dexamethasone administration post-impacted third molar removal surgery.

Materials and Methods: This prospective comparative study included 45 patients with Class II and position B type of impaction (according to Pell and Gregory’s classification). Patients were randomly divided into three groups. Group A, B, C patients received 8mg dexamethasone immediately post-surgical tooth removal through the IV, SM, and IM route, respectively. Assessment of swelling, mouth opening, and pain was done at intervals of 1st, 3rd, and 7th post-operative days.

Results: The average age of the patients was 27 years. The average time taken was 20 min 40 s. The IV group showed minimal swelling and better pain control on the 3rd post-operative day (statistically significant). All three routes showed comparable mouth opening results.

Conclusion: IV administration of dexamethasone post-third molar surgery has been the traditional way because of its faster onset of action and increased efficacy; the IM and SM routes are also comparably effective and have their own advantages.

Keywords: Dexamethasone, route of administration, third molar surgery

How to cite this article: Vivek GK, Vaibhav N, Shafath A, Imran M. Efficacy of intravenous, intramassetric, and submucosal routes of dexamethasone administration after impacted third molar surgery: A randomized, comparative clinical study. J Adv Clin Res Insights 2017;4:3-7.

Received: 01 February 2017;

Accepted: 14 February 2017


3.ORIGINAL ARTICLE

Comparison of sorption, solubility, and flexural strength of four resin luting cements in three different media: An in vitro study

Tejendra N. Wadambe, B. Uma Maheswari, Achut R. Devarhubli

Year:2017 | Month:January-February | Volume:4 | Number:1 | Pages No:8–12 | No. of Hits: 460


ABSTRACT

Background: The clinical success and durability of luting cements are determined by structural integrity and dimensional stability. Sorption and solubility resin luting cements in food-simulating solutions has not been studied sufficiently.

Aims and Objectives: To compare the sorption, solubility, and flexural strength of resin luting cements in artificial saliva, ethanol:water (1:1) and distilled water at 37°C.

Materials and Methods: Four commercially available resin cements were selected. Disk- and rectangular-shaped samples will be prepared according to ISO standard-4049. Out of 160 specimens, 120 disc-shaped specimens will be subjected to sorption and solubility analysis. 40 rectangular-shaped specimens will be subjected for flexural strength analysis.

Results: The result of the study clearly depicted that highest water sorption was observed for GC Fuji Cem in distilled water and artificial saliva media. For Composite Ionomer highest sorption was observed in ethanol:water medium. Panavia F showed least sorption in all three media. GC Fuji Cem exhibited more solubility in artificial saliva and ethanol:water (1:1) media, Composite Ionomer showed more solubility in distilled water medium. Secure luting agent showed least solubility in all three media. Highest flexural strength was observed by Panavia F and least by Tokeyoma Ionomer.

Conclusion: Within the limitation of this study resin luting (Panavia F and Secure) agents showed least sorption, solubility, and highest flexural strength than compared to resin reinforced glass ionomer cement (GC Fuji Cem and Tokeyoma Ionomer).

Keywords: Dissolution, flexural strength, luting agents, resin cements, solubility sorption

How to cite this article: Wadambe NT, Maheswari BU, Devarhubli AR. Comparison of sorption, solubility, and flexural strength of four resin luting cements in three different media: An in vitro study. J Adv Clin Res Insights 2017;4:8-12.

Received: 30 January 2017;

Accepted: 25 February 2017


4.REVIEW ARTICLE

Human immunodeficiency virus and its management in dentistry

H. B. Swetha, Thokala Dhamodaran, Swarna Sudeeshna

Year:2017 | Month:January-February | Volume:4 | Number:1 | Pages No:13–15 | No. of Hits: 168


ABSTRACT

Human immunodeficiency virus (HIV) infection is a serious disorder affecting the immune system; the body’s normal defense against infection breaks down. Oral health care workers can contribute to the early diagnosis, prevention, and treatment of HIV. The oral health management of HIV-infected patients should focus on the provision of dental care and treatment of the oral manifestations of the disease. Despite the fact that significant advances in the pathogen and management of the oral manifestations of HIV have been made, more research is required to elucidate the long-term effects in the future.

Keywords: Human immunodeficiency virus, infection control, oral infections

How to cite this article: Swetha HB, Dhamodaran T, Sudeeshna S. Human immunodeficiency virus and its management in dentistry. J Adv Clin Res Insights 2017;4:13-15.

Received: 01 Jan 2016;

Revised: 10 Jan 2017


5.CASE SERIES

Alveolar soft part sarcoma in childhood: A report of two cases and review of literature

K. R. Chatura, Sravani Doradla, Shivayogi Kusagur

Year:2017 | Month:January-February | Volume:4 | Number:1 | Pages No:16–20 | No. of Hits: 535


ABSTRACT

Background: Alveolar soft part sarcoma (ASPS) is a rare, distinctive soft tissue sarcoma, typically occurring in young people. In children, a substantial percentage of cases occur in the head and neck, often in the orbit or tongue. Although it displays a relatively indolent clinical course, the ultimate prognosis is poor with late metastases.

Aims and Objectives: Review of literature to give an insight into the current knowledge about this enigmatic tumor, in terms of genetic and diagnostic aspects.

Materials and Methods: Clinical, radiological, and morphological features of two cases, an 8-year-old female with tongue lesion and a 14-year-old female with orbital lesion are described. Immunohistochemistry (IHC) with a panel of antibodies was performed.

Results: Clinical presentation and microscopic features were remarkable in two young females, one in the tongue and another in the orbit and similar to other case reports. The use of TFE3 for IHC established the diagnosis.

Conclusion: Alveolar soft-part sarcoma remains an enigma clinically. ASPS should be considered in the differential diagnosis of pediatric head and neck masses with a solid morphology.

Keywords: Alveolar soft part sarcoma, orbit, tongue, Transcription factor E3

How to cite this article: Chatura KR, Doradla S, Kusagur S. Alveolar soft part sarcoma in childhood: A report of two cases and review of literature. J Adv Clin Res Insights 2017;4:16-20.

Received: 15 Dec 2016;

Accepted: 02 Feb 2017


6.CASE SERIES

Esthetic provisional replacement of a hopeless anterior tooth by natural pontic: A case series

Shivanand Aspalli, Mukta V. Sanikop, G. Nagappa, Anupama Desai, Reetika Gaddale

Year:2017 | Month:January-February | Volume:4 | Number:1 | Pages No:21–23 | No. of Hits: 578


ABSTRACT

Sudden tooth loss in the anterior region can be due to trauma, periodontal disease, or endodontic failure. The loss of anterior teeth can be psychologically and socially damaging to the patient. The case reports here present a novel technique for replacing an anterior tooth, in which the patient’s natural tooth was used as a pontic. The natural tooth pontic was stabilized in the extraction socket with a resin wire splint as a provisional restoration to maintain the gingival architecture while the permanent bridge was being constructed.

Keywords: Esthetics, fiber reinforced composite, hopeless prognosis, natural tooth pontic, provisional restoration

How to cite this article: Aspalli S, Sanikop MV, Nagappa G, Desai A, Gaddale R. Esthetic provisional replacement of a hopeless anterior tooth by natural pontic: A case series. J Adv Clin Res Insights 2017;4:21-23.

Received: 01 Dec 2016;

Accepted: 10 Feb 2017


7.CASE REPORT

Spindle cell carcinoma of the oral cavity

Pournima Godge, Pavitra Vibhakar, Sandip Kulkarni, Shubhra Sharma, Monica Yadav

Year:2017 | Month:January-February | Volume:4 | Number:1 | Pages No:24–26 | No. of Hits: 881


ABSTRACT

Spindle cell soft tissue neoplasms are rarely reported in the oral cavity and account for less than 1% of all tumors. Spindle cell carcinoma (SpCC) synonymously called sarcomatoid tumor occurs mainly in the upper aerodigestive tract. This peculiar malignant neoplasm predominantly affects males in 6-7th decades of life. SpCC is potentially aggressive with a high incidence of metastases. Its precise and early diagnosis is the key to good prognosis. We report a case of SpCC in a 50-year-old male patient with special reference to histogenesis of this entity. SpCC is an aggressive variant of squamous cell carcinoma which needs to be identified and differentiated from the other spindle cell tumors for proper treatment.

Keywords: Sarcomatoid carcinoma, spindle cell carcinoma, squamous cell carcinoma variant

How to cite this article: Godge P, Vibhakar P, Kulkarni S, Sharma S, Yadav M. Spindle cell carcinoma of the oral cavity. J Adv Clin Res Insights 2017;4:24-26.

Received: 11 Dec 2016;

Accepted: 20 Feb 2017


8.CASE REPORT

Interstitial lipomatosis of minor salivary gland: Fight for a place with sialolipoma

S. Suma, B. Veerendra Kumar, Amrita Samanta, Roopa P. Gaddagimath, Sarita Yanduri, M. G. Madhura

Year:2017 | Month:January-February | Volume:4 | Number:1 | Pages No:27–30 | No. of Hits: 495


ABSTRACT

The aim of this article is to report an uncommon lipomatous minor salivary gland (MSG) lesion of the upper lip that was diagnosed with pathological insight and clinical correlation. Differential diagnosis of fat containing salivary gland (SG) tumors will also be discussed. MSG lesions constitute a diverse group encompassing non-neoplastic lesions, benign neoplasms, and malignant neoplasms of varying grades. A rare subset among these includes the lipomatous SG lesions. Interstitial lipomatosis (IL) is an overgrowth of adipose tissue throughout the SG, that should be histologically differentiated from sialolipoma and infiltrating lipoma, which is neoplasms. The former is associated with systemic conditions while the latter is not. This case is of IL in a 55-year-old woman with hypothyroidism. A search in English literature did not reveal any cases of IL of the upper lip. The fact that SG neoplasms are more common in the upper lip than non-neoplastic lesions adds to the rarity of this case. Thus, this report adds another entity in the differential diagnosis of upper lip lesions and underlines the need to differentiate it from lipomatous neoplasms.

Keywords: Hypothyroidism, interstitial lipomatosis, minor salivary gland, sialolipoma

How to cite this article: Suma S, Kumar BV, Samanta A, Gaddagimath RP, Yanduri S, Madhura MG. Interstitial lipomatosis of minor salivary gland: Fight for a place with sialolipoma. J Adv Clin Res Insights 2017;4:27-30.

Received: 02 Jan 2017;

Accepted: 28 Feb 2017