Journal of Advanced Clinical and Research Insights

Vol. 6 | No.3 | May-June 2019 Issue

1.ORIGINAL ARTICLE

Morphometric assessment of mental foramen for gender prediction using panoramic radiographs in the West Bengal population – A retrospective digital study

Abha Rani, Varsha Kanjani, Deepak Kanjani, Rajeshwari G. Annigeri

Year:2019 | Month:May-June | Volume:6 | Number:3 | Pages No:63-66 | No. of Hits: 130


ABSTRACT

Background: The gender testimony is of vital importance in forensic science when only craniofacial fragments are only the remains. Mandible exhibits a high level of distinct position among the genders. Different studies have well proved that mandible shows the gender dimorphism in many morphological features such as mandible height, gonial angle, bigonial width, and bicondylar width. The anatomical position of mental foramen can also be used to differentiate between gender and such skeleton metric analysis done on radiographs is found to be of more accuracy.

Aim: This study was conducted to assess the precision of mental foramen as a landmark for gender differentiation.

Materials and Methods: Three hundred panoramic radiographs were selected for mental foramen analysis. Distance from the tangential line drawn to basal bone mandible to tangential line drawn to upper and lower borders of mental foramen on bilateral sides was measured and recorded. The data cataloged were subjected to statistical analysis.

Results: The distance between mental foramen to basal bone of mandible was more in male than that to females on the bilateral aspect, which was statistically significant.

Conclusion: Mental foramen can be considered as a radiographic landmark to determine gender in the West Bengal population of India.

Keywords: Forensic odontology, gender determination, mental foramen, panoramic radiograph

How to cite this article: Rani A, Kanjani V, Kanjani D, Annigeri RG. Morphometric assessment of mental foramen for gender prediction using panoramic radiographs in the West Bengal population - A retrospective digital study. J Adv Clin Res Insights 2019;6: 63-66.

Received: 02 March 2019;

Accepted: 12 April 2019


2.ORIGINAL ARTICLE

Evaluation of 1, 5-anhydroglucitolas a salivary biomarker in Type 2 diabetes mellitus patients

M. L. Asha, B. N. Rajarathnam, N. Vinutha, H. M. Mahesh Kumar, Anu Premkumar, Rizwana Azmi

Year:2019 | Month:May-June | Volume:6 | Number:3 | Pages No:67-71 | No. of Hits: 118


ABSTRACT

Background: Diabetes mellitus (DM) being foremost clinical and public health problem accounts for 4.6 million deaths annually worldwide. Diabetes screening using saliva alternate to blood and urine could assist diabetes testing among the public.

Aims and Objectives: To assess and establish the relationship of 1, 5.anhydroglucitol (1, 5-AG) in blood and saliva among DM and normal control subjects.

Materials and Methods: A total of 30 subjects (G1) comprising hemoglobin A1C (HbA1C) confirmed type 2 DM and HbA1C confirmed 30 healthy controls (G2) were selected. Blood and whole saliva collected from G1 and G2 subjects centrifuged, aliquoted, and subjected to mass spectrometry. Quantification of 1, 5-AG in blood and saliva samples by liquid chromatography and mass spectrometry was conducted. The results obtained were subjected to statistical analysis.

Results: Statistical analysis of data depicted G1 with lower salivary, serum 1, 5-AG levels compared to G2. Moderate positive correlation between salivary 1, 5-AG levels and serum 1, 5-AG levels in G1 and G2 observed.

Conclusion: Serum 1, 5-AG levels could be predicted using the salivary 1, 5-AG levels. Therefore, 1, 5-AG in saliva could be predicted as a salivary biomarker in Type II DM patients.

Keywords: 1, 5-anhydroglucitol, chromatography, diabetes mellitus, salivary biomarker, spectrometry

How to cite this article: Asha ML, Rajarathnam BN, Vinutha N, Kumar HMM, Premkumar A, Azmi R. Evaluation of 1, 5-anhydroglucitolas a Salivary Biomarker in Type 2 diabetes mellitus patients. J Adv Clin Res Insights 2019;6: 67-71.

Received: 22 March 2019;

Accepted: 24 April 2019


3.ORIGINAL ARTICLE

Investigation of leptin levels in periodontal wound healing: A preliminary study

C. K. Sreelakshmi Bharadwaj, Karthikeyan Bangalore Varadhan, Prabhuji Munivenkatappa Lakshmaiah Venkatesh, Richa S. Gautam

Year:2019 | Month:May-June | Volume:6 | Number:3 | Pages No:72-77 | No. of Hits: 115


ABSTRACT

Background and Objectives: Leptin (Ob) is an obese protein and is known to maintain tissue integrity. Off late, there are reports that leptin aids in dermal wound healing. However, to date, there are no reports on whether leptin has a similar role in periodontal wound healing. Hence, the present study was undertaken to explore whether leptin has a similar role in periodontal wound healing.

Materials and Methods: A total of 15 patients (10 males and 5 females) diagnosed as periodontitis were selected who fell under the age range of 30-39 years. The gingival crevicular fluid was collected for leptin analysis from the study group at baseline (who acted as pre-treatment controls), 30th day following non-surgical periodontal therapy (which coincides with the surgical intervention, i.e. open flap periodontal surgery), and at the 3rd day, 14th day, and 35th day following surgical intervention which corresponds to the various phases of periodontal wound healing, acted as post-treatment tests groups. Leptin levels were determined from individual gingival crevicular fluid samples by enzyme-linked immunosorbent assay.

Results: There was a little increase in gingival crevicular fluid leptin levels following surgical intervention which was statistically not significant (P > 0.01). One-way analysis of variance and Tukey test were applied for statistical significance.

Conclusion: Within the limitations of our study, it can be concluded that there was a little and insignificant raise of leptin at various stages of periodontal wound healing. Hence, it is not clear whether leptin aids in periodontal wound healing and maintains tissue integrity and homeostasis. At the same time, we cannot categorically deny the role of leptin in periodontal wound healing.

Keywords: Gingival crevicular fluid, leptin, periodontal disease, periodontal wound healing

How to cite this article: Bharadwaj CKS, Varadhan KB, Venkatesh PML, Gautam RS. Investigation of leptin levels in periodontal wound healing: A preliminary study. J Adv Clin Res Insights 2019;6: 72-77.

Received: 14 March 2019;

Accepted: 24 April 2019


4.REVIEW ARTICLE

The dynamics of pink and white esthetics in complete denture

V. Anand, P. S. Manoharan

Year:2019 | Month:May-June | Volume:6 | Number:3 | Pages No:78-82 | No. of Hits: 114


ABSTRACT

Esthetics plays an important role in the success of the complete denture prosthesis. Denture esthetics can be enhanced through the application of the concepts and proportions of dental esthetics. These include the selection of teeth form, size, shade and position of the teeth, and the denture base material. To create an individualized esthetic appearance to the patient, a characterized complete denture can be fabricated. Modifications are made in the teeth or the denture bases to make it appear more natural for that particular individual. This paper reviews the concepts and techniques of factors governing the pink and white esthetics of complete denture.

Keywords: Complete denture, denture characterization, esthetics, tooth selection

How to cite this article: Anand V, Manoharan PS. The dynamics of pink and white esthetics in complete denture. J Adv Clin Res Insights 2019;6: 78-82.

Received: 16 March 2019;

Accepted: 26 April 2019


5.REVIEW ARTICLE

Role of epithelial–mesenchymal transition in orofacial development - An insight

Sumita Banerjee, Saikat Mukherjee, D. B. Nandini, N. G. Sanjeeta, P. Aparna Devi, Pallav Singhal

Year:2019 | Month:May-June | Volume:6 | Number:3 | Pages No:83-85 | No. of Hits: 116


ABSTRACT

Epithelial-mesenchymal transition, commonly known as EMT, plays the dominant role in the developmental process, wound repair and tissue regeneration, and metastasis. EMT is classified into Type I, Type II, and Type III based on the molecular pathway it affects. Various molecular players such as transcription factors, growth factors, and cytokines play a significant role in the transition from epithelial cell type to mesenchymal cell type by change in the cell surface markers as well as the physiological changes such as increased mobility and invasiveness of the altered cell. In orofacial development, EMT plays a crucial role in organogenesis such as salivary gland development and tooth development. It is also contributory to palatogenesis.

Keywords: Epithelial-mesenchymal transition, molecular markers, palate development, salivary gland development, tooth development

How to cite this article: Banerjee S, Mukherjee S, Nandini DB, Sanjeeta NG, Devi PA, Singhal P. Role of epithelial-mesenchymal transition in orofacial development - An insight. J Adv Clin Res Insights 2019;6:83-85.

Accepted: 17 March 2019;

Received: 28 April 2019


6.REVIEW ARTICLE

Genetics in an orthodontic perspective

G. R. Raveendra Varma, B. Harsha, Santosh Palla, S. P. Amulya Sravan, J. Raju, K. Rajavardhan

Year:2019 | Month:May-June | Volume:6 | Number:3 | Pages No:86-90 | No. of Hits: 122


ABSTRACT

Genetics is the science concerned with the structure and function of all genes in different organisms. Malocclusion is a manifestation of genetic and environmental interaction on the development of the orofacial region. It is important to consider genetic factors to understand the cause of existing problems, which has influence the outcome of treatment. The review aims to provide information to the dental practitioner and orthodontist on basics of genetics and common disorders with gene impairments. These genetic factors in turn have an impact on outcome of orthodontic treatment.

Keywords: Gene mapping, gene therapy, genetics, homeobox, mutations, orthodontics, single-nucleotide polymorphisms

How to cite this article: Varma GRR, Harsha B, Palla S, Sravan SPA, Raju J, Rajavardhan K. Genetics in an orthodontic perspective. J Adv Clin Res Insights 2019;6:86-90.

Received: 16 March 2019;

Accepted: 18 April 2019


7.CASE REPORT

Surgical correction of alveolar ridge defect with subepithelial connective tissue graft: A Case report

Renu Gupta, Nitai Debnath, Sumita Banerjee, Vikas Kumar

Year:2019 | Month:May-June | Volume:6 | Number:3 | Pages No:91-93 | No. of Hits: 120


ABSTRACT

Localized alveolar ridge defect in the partially edentulous maxillary anterior region creates an esthetic challenge for the restorative dentist. The formation of black triangle and residual space at the pontic ridge interface makes the prosthesis esthetically unpleasant and biologically unhealthy. Hence, the surgical correction of localized ridge defect has paramount importance before prosthetic replacement.

Keywords: Black triangle, Emergence profile, pontic, porcelain-fused metal bridge

How to cite this article: Gupta R, Debnath N, Banerjee S, Kumar V. Surgical correction of alveolar ridge defect with subepithelial connective tissue graft: A Case report. J Adv Clin Res Insights 2019;6:91-93.

Received: 11 March 2019;

Accepted: 18 April 2019


8.CASE REPORT

Microveneers and digital smile designer: Planning for a patient with bruxism: A 1-year follow-up

Adriana Cristina Zavanelli, dos Santos Neto Otavio Marino, Moraes Dálete Samylle Ferreira, de Alexande Rodrigo Sversut, Zavanelli Ricardo Alexandre, Mazaro José Vitor Quinelli

Year:2019 | Month:May-June | Volume:6 | Number:3 | Pages No:94-99 | No. of Hits: 126


ABSTRACT

The present case report describes the use of digital smile design for a clinical trial execution, involving periodontal and restorative procedures and preservation with microveneers. This approach allows for more enamel preservation and, as a consequence, more predictable bonding, biomechanics, and esthetics. Such results improve harmonic esthetic appearance based on predictable procedures. At the end of the treatment, a stabilizing plate was installed for the protection of the microveneers and the elements. The patient was very satisfied with the new smile, as the treatment considered personal wishes regarding the shape, size, alignment, and contour, also considering the control of bruxism with the use of a stabilizing plate.

Keywords: Dental veneers, digital planning, esthetics, operative dentistry, temporomandibular joint dysfunction syndrome

How to cite this article: Zavanelli AC, dos Santos Neto OM, Moraes DSF, Alexandre RS, Zavanelli RA, Mazaro JVQ. Microveneers and digital smile designer: Planning for a patient with bruxism: A 1-year follow-up. J Adv Clin Res Insights 2019;6: 94-99.

Received: 02 March 2019;

Accepted: 29 April 2019