Journal of Advanced Clinical and Research Insights

1.EDITORIAL

Curbing the tobacco menace – An oral diagnostician’s responsibility

Durga Rajaram Okade Acharya
[Year:2019] [Month:March-April] [Volume:6 ] [Number:2] [Pages No:32] [No. of Hits: 110]
  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jcri.254]

ABSTRACT

Tobacco was introduced by the Portuguese to India 400 years ago and many years after that the British reintroduced it to our country. India is the third largest tobacco grower in the world and 65% of the men and 38% of the women consume tobacco.[1]

How to cite this article: Acharya DRO. Curbing the tobacco menace - An oral diagnostician’s responsibility. J Adv Clin Res Insights 2019;6:32

2.ORIGINAL ARTICLE

Comparative evaluation of the efficacy of systemic levamisole and antioxidant in the management of oral submucous fibrosis – A randomized control trial

Anuja Anil Shinge, Preeti Kanchan-Talreja, Deepa Das, Amita Navalkar, Prakash S. Talreja, Ashutosh Kakade
[Year:2019] [Month:March-April] [Volume:6 ] [Number:2] [Pages No:33-38] [No. of Hits: 107]
  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jcri.255]

ABSTRACT

Background: Oral submucous fibrosis (OSF) is a chronic, disabling disease involving the entire oral mucosa, mainly reported in Indian population. A number of treatment modalities have been tried, but none of these have been completely therapeutic. Levamisole, an immunomodulator, has been reported to be beneficial in oral mucosal lesions, but there are hardly any studies reported in literature for OSF patients, and hence, the study was taken up.

Aim: This study aims to compare the efficacy of levamisole with antioxidant for the assessment of burning sensation and mouth opening in OSF patients.

Materials and Methods: A total of 60 patients clinically diagnosed of OSF were selected for the study. We assessed patients for burning sensation and mouth opening. Patients were divided into four groups according to staging of OSF (More et al., classification), then randomly subdivided into three groups to dispense medicines. Group I patients received levamisole, 150 mg once daily for 3 alternate weeks, Group II patients received antioxidant BID for 6 weeks, and Group III patients received levamisole and antioxidant both. The patients were followed up for 2 months.

Results and Conclusion: The results proved that levamisole, antioxidant, and the combination of both showed significant improvement in mouth opening and reduction in burning sensation

Keywords: Cap. Antoxid, tab. levamisole, oral submucous fibrosis

How to cite this article: Shinge AA, Kanchan-Talreja P, Das D, Navalkar A, Talreja PS, Kakade A. Comparative evaluation of the efficacy of systemic levamisole and antioxidant in the management of oral submucous fibrosis - A randomized control trial. J Adv Clin Res Insights 2019;6: 33-38.

Received: 02 February 2019;

Accepted: 11 March 2019

3.ORIGINAL ARTICLE

Frequency of oral mucosal lesions among tobacco chewers: A cross-sectional survey

Archana Yadav, Kruthika S. Guttal, Krishna Burde
[Year:2019] [Month:March-April] [Volume:6 ] [Number:2] [Pages No:39-42] [No. of Hits: 105]
  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jcri.256]

ABSTRACT

Background: An assortment of oral mucosal sores and conditions is related with the propensity for smoking and biting tobacco, and a large number of these convey a potential hazard for the advancement of disease. There have been no examinations that report the commonness of propensities and related oral changes in the populace in Dharwad district, Karnataka, South India.

Aims and Objectives: This study aims to evaluate the effect of frequency, duration, and type of chewable tobacco products on the incidence and severity of oral lesions (leukoplakia, oral submucous fibrosis, and tobacco-induced lichenoid reaction) among the users in North Karnataka.

Materials and Methods: A hospital-based, cross-sectional study was carried out at SDM Dental College (Dharwad, Karnataka). A total number of 90 subjects (30 patients with OSMF, 30 patients with leukoplakia, and 30 patients with tobacco-induced lichenoid reaction) attending the dental hospital were interviewed and examined by trained professionals to assess any oral mucosal changes.

Results: Oral mucosal lesions were found in all the subjects who had tobacco chewing habits. Of 90 patients (65 males and 25 females), 40 patients had a habit of chewing betel quid with tobacco (44%) and 20 patients were gutkha chewers (22%) followed by 20 patients with a habit of chewing betel quid with areca nut (22%) and 10 patients with a habit of chewing pan masala (10%). The present study showed a higher frequency OSMF in patients with gutkha chewing habits (90%), whereas patients who had a habit of chewing tobacco with betel quid had more changes of leukoplakia (70%). It was also found that patients who had habit of chewing pan masala and betel quid with areca nut had more changes of lichenoid reaction. In the present study, we found that of all the 90 patients, 70% of the patients (63 patients) were asymptomatic, whereas 30% of the patients (27 patients) were symptomatic having complains of burning sensation (23 patients) and restricted mouth opening (4 patients).

Conclusion: The study demonstrated that the danger of the advancement of oral lesions related with tobacco chewing is very high. The study fortifies the relationship of OSF with gutkha and areca nut biting while leukoplakia was normal in subjects who had a propensity for biting tobacco with betel quid that the risk of the development of oral lesions associated with tobacco chewing is quite high. The study reinforces the association of OSF with gutkha and areca nut chewing, whereas leukoplakia was common in subjects who had a habit of chewing tobacco with betel quid.

Key words: Betel quid, gutkha, oral cancer, oral lesions, pan masala, tobacco

How to cite this article: Yadav A, Guttal KS, Burde K. Frequency of oral mucosal lesions among tobacco chewers: A cross-sectional survey. J Adv Clin Res Insights 2019;6: 39-42.

Accepted: 12 February 2019;

Received: 15 March 2019

4.REVIEW ARTICLE

A Review on Oral and Dental Pain

Durga Okade, Tejavathi Nagaraj, Sushant Anant Pai, Swati Saxena, Poonam Sahu, Arundhati Biswas
[Year:2019] [Month:March-April] [Volume:6 ] [Number:2] [Pages No:43-47] [No. of Hits: 109]
  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jcri.257]

ABSTRACT

Orofacial pain (OFP) occurs due to multiple causes, and hence, it is a broad term which comprises of various diseases of orofacial structures, central nervous system or peripheral or psychological abnormality, intracranial pathology, rheumatoid disease, or generalized musculoskeletal disease, or it can be a referred pain from cervical muscles. It is a great challenge for clinicians to deal with all these conditions, as the response to the same noxious stimulus varies from individual to individual. Therefore, to provide an appropriate and optimal treatment, the clinician should acquire a thorough knowledge to make a proper diagnosis. Thereby, this article puts some light on the information related to OFP and an insight into its differential diagnoses.

Keywords: Orofacial pain, pain, pain perception, theories of pain

How to cite this article: Okade D, Nagaraj T, Pai SA, Saxena S, Sahu P, Biswas A. A Review on Oral and Dental Pain. J Adv Clin Res Insights 2019;6:43-47.

Accepted: 01 February 2019;

Received: 02 March 2019

5.REVIEW ARTICLE

Desquamative gingivitis: Does the gingiva tell you more than what meets the eye? A comprehensive review

Grace Tara Paul
[Year:2019] [Month:March-April] [Volume:6 ] [Number:2] [Pages No:48-52] [No. of Hits: 111]
  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jcri.258]

ABSTRACT

Several systemic diseases and conditions, allergic reactions to various agents, and psychological stress manifest in different ways on the gingiva. Desquamative gingivitis is one such condition that presents as erythema, ulcerations, or erosions on the gingiva and may be indicative of a bigger underlying condition/disease. While examining the oral cavity, we often forget that it is an integral part of the rest of the body, the oral mucosa, particularly the gingiva, is the site where several systemic diseases and conditions manifest. This review paper attempts to throw light on the various conditions and diseases manifesting as desquamative gingivitis, the importance of clinical examination, and proper history recording, along with relevant histopathological and immunological investigations. It also looks into the different modalities of management and treatment of desquamative gingivitis.

Keywords: Erosions, erythema, stress, ulcerations

How to cite this article: Paul GT. Desquamative gingivitis: Does the gingiva tell you more than what meets the eye? A comprehensive review. J Adv Clin Res Insights 2019;6:48-52.

Received: 11 February 2019;

Accepted: 22 March 2019

6.CASE REPORT

Oral lichen planus: A case series

Durga Okade, Tejavathi Nagaraj, Poonam Sahu, Swati Saxena, Arundhati Biswas, Soniya Kongbrailatpam
[Year:2019] [Month:March-April] [Volume:6 ] [Number:2] [Pages No:53-56] [No. of Hits: 111]
  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jcri.259]

ABSTRACT

Oral reticular lichen planus (OLP) is a common mucocutaneous disease of uncertain cause. The disease seems to be autoimmune disease in which the apoptosis is triggered by CD8+T cells and non-specific mechanisms such as activation of matrix metalloproteinase and degranulation of mast cell. It is most often reported in patients with 30-60 years of age, group with a gender predilection, and female-to-male ratio of 1.4:1. This article is a case series of different forms and appearances of OLP with etiopathogenesis, clinical presentation, oral findings, diagnosis, malignant transformation potential, and treatment of OLP.

Keywords: Cytotoxic CD8+ T cells, matrix metalloproteinase, mucocutaneous

How to cite this article: Okade D, Nagaraj T, Sahu P, Saxena S, Biswas A, Kongbrailatpam S. Oral lichen planus: A case series. J Adv Clin Res Insights 2019;6:53-56.

Received 09 February 2019;

Accepted 20 March 2019

7.CASE REPORT

A concurrent kissing lesion of palate: A case report

Bhavana T. Veerabasavaiah, Tejavathi Nagaraj, Noori Ghouse, Leena James
[Year:2019] [Month:March-April] [Volume:6 ] [Number:2] [Pages No:57-59] [No. of Hits: 113]
  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jcri.260]

ABSTRACT

Median rhomboid glossitis (MRG) is well-delineated erythematous area seen in the dorsum aspect of tongue posteriorly along the midline. It is diamond (rhomboid) in shape where the two ends are in anteroposterior direction. The constant contact of MRG to the area of the palate leads to the formation “kissing lesion” or area of erythematous/roughness patch. Association of candidiasis as oral opportunistic infection is most commonly affecting people whose immune system is compromised due to several etiologies.

Keywords: Candidiasis, kissing lesion, median rhomboid glossitis

How to cite this article: Veerabasavaiah BT, Nagaraj T, Ghouse N, James L. A concurrent kissing lesion of palate: A case report. J Adv Clin Res Insights 2019;6:57-59.

Received 13 February 2019;

Accepted 20 March 2019

8.CASE REPORT

Case report on oral leukoplakia with superadded fungal infection

Mahalaxmi L. Lature, Krishna Burde
[Year:2019] [Month:March-April] [Volume:6 ] [Number:2] [Pages No:63-66] [No. of Hits: 114]
  • [PDF]
  • [Abstract]
  • [DOI : 10.15713/ins.jcri.261]

ABSTRACT

Leukoplakia of the oral cavity is a precancerous lesion has a malignant potential and life threatening if not diagnosed early. The predisposing factor of Candida in leukoplakia has been a matter of argument of late. The fungus Candida albicans intrusion was proposed to be a noteworthy hazardous component for the threatening change of oral leukoplakia, and furthermore, it was found to be related with certain clinical attributes, for example, tissue injury, size of the lesion, site in the oral cavity, dysplastic changes, and tobacco use. Females as compared to males had a greater risk of malignant changes which was demonstrated in few researches. Various treatment modalities are incorporated to manage this condition which includes antioxidant therapy, supplements of carotenoids, and antifungal agents.

Keywords: Candidal leukoplakia, oral leukoplakia, oral squamous cell carcinoma, premalignant disorder

How to cite this article: Lature ML, Burde K. Case report on oral leukoplakia with superadded fungal infection. J Adv Clin Res Insights 2019;6:60-62.

Received: 01 Feb 2019

Accepted: 26 March 2019